Scientist surprised by discovery of ‘99%’ effective, cheap COVID treatment

Scientist surprised by discovery of ‘99%’ effective, cheap COVID treatment

University of Florida researcher tells WND people already reporting results from Benadryl

Art Moore
WND News Center

The scientist who combined two widely available over-the-counter compounds that inhibited the novel coronavirus by 99% in early tests told WND he’s hopeful his treatment will be available “within months.”

Dr. David Ostrov
Dr. David Ostrov
Courtesy UF Health

“An FDA-approved treatment could be in sight within months if pharmaceutical companies utilize existing clinical trial resources,” said Dr. David Ostrov in an email interview with WND.

Ostrov, an immunologist and associate professor in the University of Florida College of Medicine’s department of pathology, immunology and laboratory medicine, combined diphenhydramine, which is marketed as Benadryl, and lactoferrin, a protein in milk, as WND reported in December.

“My prediction is that antiviral drug combinations, such as diphenhydramine and lactoferrin, will provide a similar level of benefit as Regeneron monoclonal antibodies, Pfizer and Merck antivirals, at less than 1/100 the cost of those therapies,” he told WND.

Ostrov said he knew he was facing an uphill battle in his effort to find a combination of cheap, safe and available drugs to combat COVID-19.

“I expected failure, but you never know until you try,” he said. “My reaction was surprise.”

His study, with early results showing 99% efficacy in inhibiting replication of the SARS-CoV-2 virus, was published Nov. 20 in the journal Pathogens.

Ostrov told WND he’s been in communication with people who wonder if their use of the compounds has helped prevent them from getting COVID-19.

He noted that “anecdotal stories are certainly not proof of efficacy,” but many people have contacted him about diphenhydramine and lactoferrin, and their results “are difficult to ignore.”

“For many people, they say everyone around them got COVID, but not them,” Ostrov said.

And they ask the professor if diphenhydramine and/or lactoferrin.

“Without placebo controlled clinical trials, we will not have a definitive answer,” he said. “The answer for now, though, is maybe.”

Ostrov mentioned a contact who takes a daily dose of Benadryl and regularly drinks milk. She said she had been in close contact for hours with someone who was hospitalized the next day for COVID-19. But after waiting five days from the time of exposure, she tested negative for COVID.

He cautioned that people “considering their own concoction should understand that our experiments were carried out with human lactoferrin, not cow.” And the lactoferrin he used was purified in a special way to enhance its antiviral properties and is not likely to be found on the shelf.

People should consult with their physician, Ostrov said, before taking any drug for a use other than its intended use.

“Even though historically there are relatively few adverse events reported for diphenhydramine and lactoferrin, it should be noted that long term use of any medication, or combination of medications, could have unexpected consequences,” he said.

Ostrov said he hopes that once FDA-approved, “people may benefit from this antiviral drug combination for two-to-three month intervals during each wave of COVID infections.”

Read the Q&A:

WND: I imagine there was elation in finding 99% effectiveness in inhibiting replication of the virus that has changed the world. Can you describe your reaction and your hopes for this possible treatment?

DR. OSTROV: We were aiming to find a combination of drugs that would work much better against SARS-CoV-2 when used together. I expected failure, but you never know until you try. My reaction was surprise.

My hope is that this antiviral drug combination will be shown to both prevent and treat COVID effectively (in placebo controlled clinical trials).

Since these drugs are stable at room temperature, economical, widely available and have long histories of safety, diphenhydramine and lactoferrin have the potential to inhibit replication of the coronavirus (and the emergence of new variants) on a global scale.

WND: Can you explain in layman’s terms why these two compounds appear to be effective in inhibiting SARS-CoV-2?

DR. OSTROV: SARS-CoV-2 causes cells to undergo stress in a way that creates a good environment for the virus to replicate.

Diphenhydramine binds a specific protein involved in cell stress and blocks the virus from creating a good environment for replication.

Lactoferrin has antiviral activity for different reasons. Lactoferrin is thought to repel virus particles from target cells (by binding lipoproteins on cell surfaces). Lactoferrin is also thought to suppress virus replication.

WND: How did you come to find out that diphenhydramine was potentially effective against COVID-19?

DR. OSTROV: The story started before SARS, when my lab was studying drugs that bind ACE2, the molecule that turned out to be the receptor for SARS and SARS-CoV-2.

We previously found that an antihistamine (hydroxyzine) bound ACE2, and in 2020 were able to test the ability of this drug to inhibit SARS-CoV-2 in the lab. It was an “aha” moment when the data clearly showed that a common antihistamine inhibited the virus that causes COVID. Different scientists at the University of Florida College of Medicine used different isolates of SARS-CoV-2, and the results agreed with each other. An antihistamine can inhibit the virus!

We then realized that there may be similar drugs that could inhibit the virus, perhaps even over-the-counter drugs. But which drugs?

We collaborated with investigators and UCSF where they examined the medical records for more than 219,000 people tested for SARS-CoV-2. They found that usage of diphenhydramine was associated with a lower incidence of SARS-CoV-2. In other words, in this population, people were less likely to be infected with COVID if they used diphenhydramine.

Why would taking an allergy pill lead to lower risk of COVID? There could be many reasons, but is it possible that a simple allergy pill can directly inhibit the virus that causes COVID?

We did the experiments at the University of Florida College of Medicine, and the data was published in a peer reviewed journal. Diphenhydramine exhibits direct antiviral activity against SARS-CoV-2. Diphenhydramine inhibits virus replication, inhibits virus shedding and inhibits host cell killing.

WND: Obviously, treatments for COVID-19 are needed now, but further research and human trials are necessary, which take time. Assuming the further trials affirm your early findings, how long might it be before such a treatment is available to the public?

DR. OSTROV: An FDA-approved treatment could be in sight within months if pharmaceutical companies utilize existing clinical trial resources.

My prediction is that antiviral drug combinations, such as diphenhydramine and lactoferrin, will provide a similar level of benefit as Regeneron monoclonal antibodies, Pfizer and Merck antivirals, at less than 1/100 the cost of those therapies.

WND: What is your caution to people who might try their own concoction, perhaps with Benadryl and lactoferrin? Could there be any harmful consequences?

DR. OSTROV: People considering their own concoction should understand that our experiments were carried out with human lactoferrin, not cow. The lactoferrin we used was purified in a special way to enhance its antiviral properties. People are not likely to find this on the shelf.

Could there be harmful consequences? People should consult with their physician before taking any drug “off-label,” meaning using a drug for a use other than its intended use.

Even though historically there are relatively few adverse events reported for diphenhydramine and lactoferrin, it should be noted that long term use of any medication, or combination of medications, could have unexpected consequences.

My hope is that people may benefit from this antiviral drug combination for two-to-three month intervals during each wave of COVID infections.

WND: Are there any treatments for COVID-19 available now that you have found to be effective?

DR. OSTROV: Current treatments seem to speed up recovery, but not as dramatically as we would like. We can expect that many monoclonal antibodies used for treatment will exhibit reduced effectiveness as circulating viruses acquire more mutations, such as in omicron.

Based on our understanding of the mechanism of action, mutations in the spike protein are not expected to impact the antiviral activities of diphenhydramine and lactoferrin. This is important because it means that we may be able to inhibit the virus regardless of mutations that arise in the spike protein.

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70 Comments

      1. Betty

        Totally agree. Who is fact checking the media. And who is fact checking the Fact Checkers?
        This pandemic would be over if the media was fact checked and not allowed to censor out what doesn’t fit the $$ narrative. It is hard to believe that so many groups are in bed with the scheme and can be bought to silence reputable scientists and doctors and sell us basically into a dictatorship.

        Reply
        1. wbrab

          Whose fact checking the online Russian and Chinese bots set up to tell gullible, uneducated Americans that doctors are trying to kill them but urine will save them? No one. It’s killing people. 3,300 dead yesterday. Flu kills 150 a day.

          Everyone dying is unvaccinated. It’s sick.

          Reply
          1. Betty

            You only know this from what you have been told, not from first hand knowledge. Figures dont Lie; but liars figure. We are seeing that first hand as we see the way figures are manipulated. One gross example is that people in the hospital who have been vaccinated but less than 14 days before hospitalization are considered unvaxxed. That is a blatant lie and the truly unvaxxed get those numbers counted against them. Look at both sides people.

          2. Betty

            Fact check: Not everyone dying is unvaccinated. Some have died from or with COVID, even though vaccinated, and some have died because they were vaccinated. This is fact.

      1. wbrab

        lol

        It’s so hard to believe that there are people so uneducated, so foolish as to think drinking milk, urine, and Benadryl is safe… but a vaccine might kill them. In the meantime, COVID-19 killed 3,300+ of you morons yesterday. And 2,000 more will die today. In fact, in 19 days in January, COVID-19 has killed 26,000+ Americans. That’s flu’s annual total. In 19 days. Sick and sad world we’re living in with Russian and Chinese propagandists feeding you lies and laughing at you while you enact them.

        Reply
  1. Audi

    People might think some kind of “milk treatment” to cure C-19 is just arround the corner, not get vaccinated and some, yes, might die because of this. Clarkcountytoday.com you may be partly responsible for those peoples deaths. If somebody in my family will share this horrible fate and I can show they read your article and how it impacted their decision not to get vaccinated with the result of death, I think I might have a court case.

    Reply
    1. TJFagan

      You do you. Last I checked it’s still a free country, but that was yesterday. You should counsel your own family on misinformation….as you drive to the clinic for your 4th, 5th or 6th booster.

      Reply
      1. wbrab

        Criminal behavior, slander, and scamming people to false cures are actually highly illegal and not free. You cannot lie and tell people to do X and then have that result in their death and escape a court case. It’s called manslaughter.

        You are not free to attack people and spread falsehoods. You’re also not free to shoot up heroin, speed through red lights, or tell children that jumping of a bridge will send them to a better place.

        How stupid are Americans? Russians are probably running this site telling uneducated southerners who still knock on wood to fend off cancer all of these things. Know why? Cause they want to destroy the country.

        I don’t know a single vaccinated person who’s died. But I do know morons in Texas right now begging doctors to save them from their own stupidity.

        Reply
        1. Sheila

          Hahahaha! What the hell is WND? No doubt some nutbag, looney tune, religious rag. Pretty sure major scientific breakthroughs are not coming out in the “Clark County Today” community paper. Wow.

          Reply
    2. Betty

      Who can we take to court for the deaths of many and serious harmful results that many others live with? When will people stop blindly believing the carefully crafted propaganda that pits people against each other. Since when has only one side of a debate been allowed to be heard in a democracy?

      Reply
    3. wbrab

      Court case already under way, friend. I’ve passed this along to several federal and even state D.A’s. The issue is a lot of these sites are set up by foreign enemies laughing while Americans die. How low can we go? You’ve got people downing milk and urine because some Russian or Chinese bot told them too. Fox News latches onto that story and kills 30,000 more.

      Is the rural south really this sick?

      Reply
  2. Jay Kanta

    These claims are just as real as Malone’s or McCullough’s. That is, they’re total BS and only the right-wing clown show will ever believe it.

    Reply
    1. Anthony Lynch

      It’s a peer reviewed published article with the recommendation to move forward with clinical trials. It doesn’t claim proof that it works but recommends further study based on early data. This is exactly how science works, you come up with a theory and test it then test it again and again.

      Reply
      1. Jay Kanta

        I’m sorry, this is not how science works. What they have is called a “hypothesis” and no plausibility for it to work in humans. Do you know the difference between a theory and a hypothesis?

        Reply
  3. LivenFree

    Could be why our family who are taking antihistamines and all unvaxxes have only had a cold these last 2 years and don’t wear mask everywhere, btw we live our lives as free people. just a thought.

    Reply
    1. wbrab

      You do not live your lives as free people. You’re not allowed to drive a car as fast as you want, send your children to school with lice and demand that they be left alone, or free to do any drug you want or tell people things that might kill them and then walk away like nothing happened.

      Freedom comes with responsibility. We have laws against slander, manslaughter, and passing on infectious diseases to others knowingly. One disease that may not kill you might very well have killed your neighbors. Do you even care or are you evil?

      Reply
    2. Trumps luvs lil girls

      Why do you tell women they CAN’T live their lives free and YOU YOU YOU know what’s good for their body???? just a thoughr.

      Reply
  4. zen pig

    just read 5 comments, and it seems that folks are more interested in the political social narrative rather than read the entire paper. Let me walk you all through how science works. We observe events, and develop a hypothesis attempting to determine if our hypothesis is sound. We do invitro and in vitro invivo studies in order to determine if additional randomized large scale studies are warranted. period. It is not scientific to dismiss out of hand anything due to existing belief, or political leaning. here is the link to the research so far. https://www.mdpi.com/2076-0817/10/11/1514/htm

    Reply
  5. Erica Be Ready

    I muscle tested myself and my husband daily while we both came down with covid at home. He needed benadryl/tylenol for his headaches. I kept testing that I needed milk. So this makes sense to me.

    Reply
  6. Qub bie

    Lol, the nut job lefties. Still acting like morons as they are even when it’s peer reviewed by people who work at UCSF… These morons don’t know where that is apparently. But it’s alright, we normies can let them live in their bubble and continue one with their booster addiction. Follow your leaders call little sheep. When the shepherd comes calling for your slaughter, you’ll be the first ones to step up I’m sure.

    I’m glad other scientists are trying to find other remedies to this “plandemic”. Monoclonal antibodies seems to be off the shelves now, now that Pfizer has a bigger grasp of the booster market. Iverrmectinhad it’s short phase of success till gov decided to get involved again. Maybe because gov wanted to spend billions of tax money on buying doses from Pfizer and Moderna. I mean people are saying the shots are free… Free right?

    I was going to buy Pfizer stock when it was 40 but hesitated because fauxci said a year back the country was back in recovery… Then a few weeks later, again, he says mask up and lock up… Now Pfizer went as high as 56 or 58… Yes, the smart money people are making millions off this “pandemic.”

    Reply
    1. wbrab

      How about just using common sense? 100 years ago there was a pandemic that killed fewer people than COVID-19. That’s precisely because people back then just used common sense. If you have an infectious disease killing almost a million people, you throw on a mask and play it smart. But unvaccinated people continue to die daily by the thousands because they have no common sense.

      It’s your grave and your next missed election. 1,900 more dead today, 99% of them unvaccinated. In the meantime, the rest of the country has a head cold and is happily living life.

      Reply
      1. Dave

        Idiot I have worked through this whole thing. Taking sick people to Dr, hospital etc. Also picking up all the tests from the mobile test sites. I have cancer in chemo and still haven’t gotten it. So one size doesn’t fit all.

        Reply
      2. NJGal

        No, it’s the vaxxed that are dying, not the unvaxxed. Go take another booster shot, they are worthless but killing your immunity at the same time. Go listen to Fauci, he’s got your back LOL.

        Reply
  7. wbrab

    Let me guess, this quack also wants you to wash it down with milk and urine.

    Lots of opportunistic “doctors” out there with no ethics telling people to take anything and everything. The mortality rate dropped to .004% during this surge, so it’s possible for doctors to tell thousands of people to do “X” and people think they’re getting results from that. What’s next, hopping up and down on one foot, doctor?!

    Reply
  8. Jack

    This virus was created in Wuhan lab with Fauci in cahoots with the Chicomms. That alone deserves researching and prosecuting of all involved. There’s something wrong when all the less expensive and less invasive, non medical experiments that could be done are forbidden. I’m sick and tired of the busybodies telling me how to live!

    Reply
  9. Dave

    One size doesn’t fit all. In case some of you idiots don’t know what that means, just because you want vaccine and think it will help you doesn’t mean everyone does.
    I have worked through this whole damn thing,I have cancer, went through chemo. Have COPD. And what I do for a living puts me Around sick people everyday. I take them to there Drs and hospitals, I also pick up the tests from the mobile test sites everyday. And quite sure there are positive tests in there, have been tested 13 times always negative. Haven’t been sick accept my other two health problems. So all of you who say get vaccinated kiss My a.s it doesn’t help everyone. You still get it vaccinated or not. Oh I also don’t and haven’t worn a mask. Because I have always known they don’t work as now if t has been proven..

    Reply
  10. wbrab

    Half of this country literally has brain damage. Probably from COVID-19. I’ve given up all hope.

    If anyone was afraid the Chinese were ever going to destroy us, they have. Their constant stream of online misinformation (with the help of Russia of course) has full on given the brain damaged south the idea that urine, milk, and over the counter benadryl is going to save them from the deadliest pandemic in US history. Almost a million people are dead. 3,300 dropped dead yesterday.

    50% of the country has the national guard in their hospitals. 50% of the country is dying. They trust Twitter bots and Chinese propagandists that urine will save you but your leaders are trying to kill you. And you sit there reading these lies, believing them. It’s really sad.

    If the other 50% had vaccinated and masked, none of this would be happening. But while you’re over there drinking the urine that Russia and China fake posters told you to drink, and Fox News passed it along because your ad clicks buy their vacation homes, you’re destroying your country. And now your children will one day die of this. Because of you.

    Reply
  11. wbrab

    Note:

    This website is deleting anything that doesn’t feed you lies. Flee from it. It’s automatically deleting anything that might tell you real science.

    Enjoy your urine everyone. I hope it saves you. It didn’t save two of my family members this year. lol

    Reply
  12. wbrab

    This propaganda website will be faced with a lawsuit soon.

    It is automatically, within seconds, deleting anything that might be factual.

    There will be a day of reckoning for online websites killing Americans. Slander and defamation is not legal. You are killing human beings with your garbage. Passed this along to the justice department and may you face billions in lawsuits.

    Reply
    1. Miranda Graham

      Something swollen and red and having an allergic reaction to who knows what? Take Benadryl. Why wouldn’t it be a cure for something? It’s the bandaid to so many mystery ailments. Hungry but not hungry? Drink milk it coats your stomach. Take a vaccine that now takes a shot plus 4 boosts=5 and still won’t give more than 50% for more than a couple weeks to a month. Plus immunocompromised such as myself little to no antibody response? Sounds like we are an example of the cure but nobody is studying us. Science has always dictated you study the ones who are on the front lines and don’t get sick even when in the most danger. This scientist isn’t claiming he knows the answer. He is claiming one thing they have in common is worth looking into. And God forbid someone find a cure who isn’t influenced by the monster of money. Fact checkers? Ha. The cure will be stifled by all those touting they are protecting the weak from misinformation. All the stupid people have already been killed off by survival of the fittest. We shouldn’t fear information instead the lack of it and the freedom to sort through it and make an educated decision instead of having faith we are handed the safe truth by whom really?

      Reply
      1. MikeBear

        Take Benadryl. Why wouldn’t it be a cure for something? It’s the bandaid to so many mystery ailments.”

        Sure, and while you’re at it, drink your own pee. It’s worth a try, right?

        I don’t know what “mystery ailments” you’re talking about, but if a patient comes in with a perplexing condition, then one of the things to rule out is a possible allergic reaction, so it is likely that the first course of treatment may be with antihistamines such as Benadryl. That doesn’t mean it’s a cure-all. Moreover, we know that COVID is not an allergic reaction.

        Reply
  13. Joe Swanson

    Let these idiots have their benadryl and milk enemas… more fodder for sorryantivaxxer site. I mean: why listen to the entire scientific community when you can listen to one quack?

    Reply
  14. MikeBear

    This is an in vitro study that showed Benadryl plus lactoferrin had some ability to interfere with viral replication. You know what other drug showed “promise” in an in vitro study? Ivermectin. But no reputable subsequent study showed ivermectin to be an effective treatment. The key word here is “reputable.” Yes, there were studies that claimed ivermectin was an effective treatment, but many of those were observational studies and the one RCT that showed it to be effective was retracted because it was found to have been fraudulent. If the University of Florida wants to fund additional studies, go ahead, but I don’t see this Benadryl-lactoferrin “treatment” as being anything more than another ivermectin.

    Reply
  15. Margaret

    Great to see research on a potential inexpensive anti-viral from the land of the free, Florida.

    Another interesting pre-print study, “Altogether, our results suggest that bromelain or bromelain rich pineapple stem may be used as an antiviral.”
    Bromelain Inhibits SARS-CoV-2 Infection in VeroE6 Cells
    Here is another pre-print study about anti-viral remedies:
    “Honey and Nigella sativa (HNS) have established antiviral, antibacterial, anti-inflammatory and immunomodulatory properties.” Nigella sativa is black cumin seed.
    Honey and Nigella sativa against COVID-19 in Pakistan (HNS-COVID-PK): A multi-center placebo-controlled randomized clinical trial

    Reply
  16. Janet

    I have followed covid19 and treatments for 2 years now and your study of Diphenhydramine and Lactoferrin for Covid19 is so exciting and hopeful! What you will be up against is the big pharma of these poisionous vaccines that are on the market and the people connected to these vaccines. Follow the money as they say. FDA won’t even approve the new vaccines that have showed effectiveness. I have a question: being as both of these substances, Diphenhydramine and Lactoferrin are available without Rx, could you simply make a supplement pill with these ingredients and sell OTC? I wouldn’t think you would need the FDA’s, CDC’s or FBI’s approval. What say you?

    Reply
  17. SqueelonWow

    I was tested positive for the flu 7 days ago and began taking Allegra. Did nothing so I switched to Xyzal which I also found out 5 days in, I tested positive for COVID. The first time I took Xyzal, I felt it working for the first time 3 hours, then stopped. The second day, I felt it work for 3 hours then skipped 3 hours and then worked for the remainder. The third day, all inflammation stopped. It dried everything up. I’m now on the 4th day and will continue to take it while I still have COVID. Then I can switch to half a tablet. I think the antihistamine that cause drowsiness work the best like Benadryl or Xyzal. I knew that the histamine reaction to virus was the real culprit. Slowing down this so that my body’s white blood cells can do its job what was key in my decision to try Xyzal. My daughter takes Xyzal for children daily for her seasonal allergies and although her dad and I have COVID, she has not for any of her PCR tests. I was curious, if I was on to something and glad I found this article. A cheap drug to stop viruses and split the symptoms in half or being the symptoms down to a level of a mere headache is shocking. The antiviral drugs that costs thousands is such a rip off. We stopped taking Tylenol, Advil, flovent and Albuterol bc we don’t have inflammation. Just a miracle for antihistamines, the stronger ones, that is.

    Reply
  18. Jody

    The Loratadine immediately cleared up my “Massive Mucus Attack.” \\
    I had a Fever which is a symptom of Covid. \\
    But mucus is NOT listed as a symptom of Covid. \\
    After much discomfort, I used my antihistamine Loratadine (Clariton equivalent). \\
    I know that I am allergic to Daffodils in the house. \\
    This looks VERY suspicious to have just confirmed that I DO have a Wheat “allergy.”

    Reply
  19. Jody

    Editor. Please edit first remark for “Loratadine.”
    Please leave off these last 2 frivolous efforts to correct.
    I was confused with spelling because someone mentioned Allegra.
    My spelling for Clariton is underlined for correction.
    Allegra is not underlined for correction.

    Reply
  20. Lindacollavo

    I have found many friends who never got covid but were exposed. It became a game with me to open conversations and ask about covid I recently had a worker in my home talking about how everyone in his company, but the guy that was standing next to him, had covid. I asked about benedryl, both heads turned and said he did take bit every day because of allergies. It works. And it worked on me when I recently got covid. Clearly, I did better than my boyfriend who received monoclonal infusion. I’m not a health professional, but I do like to help people. The idea that this was an option during the pandemic really made me mad. I advertise for the U of Florida study every chance I get.

    Reply

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